DETECTION OF 2H-1,4-THIAZINE-5,6-DIHYDRO-3-CARBOXYLIC ACID (AMINOETHYLCYSTEINE KETIMINE) IN THE BOVINE BRAIN

被引：25
|
作者：
NARDINI, M
MATARESE, RM
PECCI, L
ANTONUCCI, A
RICCI, G
CAVALLINI, D
机构：
[1] UNIV CHIETI G DANNUNZIO,INST BIOCHEM SCI,CHIETI,ITALY
[2] CNR,CTR BIOL MOLEC,ROME,ITALY
来源：
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1990年 / 166卷 / 03期
关键词：
D O I：
10.1016/0006-291X(90)91000-I
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
2H-1,4-Thiazine-5,6-dihydro-3-carboxylic acid (trivial name : aminoethylcysteine ketimine) is a cyclic sulfur-containing imino acid detected in bovine brain extracts by means of three different procedures. Gas liquid chromatography of protein-free extracts of five bovine brains revealed the presence of this compound at concentrations ranging from 2 to 3 nmol/g wet weight of tissue. The enzymatic method based on the inhibition of D-amino acid oxidase activity by aminoethylcysteine ketimine together with an high-performance liquid chromatography procedure confirm the identification and quantitations obtained with gas liquid chromatography. The discovery of this compound structurally similar to pipecolic acid opens the question of its physiological role in the central nervous system. © 1990.
引用
收藏
页码：1251 / 1256
页数：6
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