Study of the Helicobacter pylori infection in chronic obstructive pulmonary disease

Background: COPD may be associated with other systemic diseases including cardiovascular diseases, diabetes, osteoporosis and peptic ulceration and Helicobacter pylori infection seems to be the main cause of PUD. Aims: The aim of this work is to study the association of H. pylori infection in chronic obstructive pulmonary disease (COPD). Subject and methods: This study was performed on 80 subjects. They were classified into two groups: Group I: 65 COPD patients. Group II: 20 healthy control subjects. COPD was diagnosed according to the Global Initiative for chronic obstructive pulmonary disease admitted at chest department of Benha University Hospital. Results: It shows that seropositivity of anti-H. pylori IgG and anti-CagA IgG was higher in COPD patients than in controls with a highly statistically significant difference (p = 0.009 and 0.047 respectively). Also the IgG level of H. pylori positive cases and CagA positive cases was higher in the COPD group than in the control group with a highly statistically significant difference (p = 0.027 and 0.0001 respectively). Conclusion: The present study suggests that patients with COPD have an increased seroprevalence of Hp infection. (C) 2016 The Egyptian Society of Chest Diseases and Tuberculosis. Production and hosting by Elsevier B.V.