EFFECTS OF KF-14363 ON LIVER FIBROSIS IN RATS WITH CHRONIC LIVER-INJURY INDUCED BY CARBON-TETRACHLORIDE

被引:8
|
作者
YOSHITAKE, I
OHISHI, E
SANO, J
MORI, T
KUBO, K
机构
[1] Pharmaceutical Research Laboratories, Kyowa Hakko Kogyo Co., Ltd., Shizuoka 411, Nagaizumi-cho, Sunto-gun
来源
JOURNAL OF PHARMACOBIO-DYNAMICS | 1991年 / 14卷 / 12期
关键词
HEPATOPROTECTION; RAT LIVER FIBROSIS; 4-HYDROXYPROLINE; CARBON TETRACHLORIDE;
D O I
10.1248/bpb1978.14.679
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The present study examined the effects of (1-[(2-thiazolin-2-yl)amino]-acetyl-4-(1,3-dithiol-2-ylidene)-2,3,4,5-tetrahydro-1H-1-benzazepin-3,5-dione hydrochloride (KF-14363) on liver fibrosis in rats with chronic liver injury induced by carbon tetrachloride (CCl4). Liver injury in male rats was induced by repeated administration of CCl4 at 0.5 ml/kg twice a week. The progression of liver fibrosis was checked in the 4th, 6th, 8th and 10th weeks using the relative amount of hepatic 4-hydroxy proline (4-hyp) to total proteine as an index of hepatic collagen. The relative amount of hepatic 4-hyp in these rats exceeded significantly that in rats not administered CCl4 by the 4th week. This progressed in proportion to the duration of CCl4 administration. In groups concurrently administered KF-14363 at 30 and 100 mg/kg/d from the 5th or 8th week of the CCl4 administration, the relative amount of hepatic 4-hyp was found to be lower in the 10th week than at the start of the KF-14363 administration. The inhibition of liver fibrosis was also observed histopathologically. The concurrently co-administration with CCl4 or KF-14363 at 30 and 100 mg/kg for 2 or 5 weeks inhibited the increases in serum transaminases and alkaline phosphatase induced by CCl4. The results show that KF-14363 inhibits liver fibrosis in a dose dependent fashion in rats with progressive liver injury.
引用
收藏
页码:679 / 685
页数:7
相关论文
共 50 条
  • [31] LIVER FIBROSIS AND PITUITARY CELL HYPERPLASIA IN CARBON-TETRACHLORIDE TREATED RATS
    INGLETON, PM
    PARSONS, MA
    UNDERWOOD, JCE
    DANGERFIELD, VJM
    JOURNAL OF PATHOLOGY, 1984, 143 (04): : A302 - A302
  • [32] ATTENUATION OF CARBON-TETRACHLORIDE (CCL4)-INDUCED LIVER-INJURY IN RATS WITH FRUCTOSE 1-6 DIPHOSPHATE (FDP)
    BOYD, T
    MIHAS, AA
    MARKOV, AK
    CLINICAL RESEARCH, 1990, 38 (04): : A970 - A970
  • [33] PROTECTIVE EFFECT OF (+)CYANIDANOL-3 IN ACUTE LIVER-INJURY INDUCED BY GALACTOSAMINE OR CARBON-TETRACHLORIDE IN THE RAT
    PERRISSOUD, D
    WEIBEL, I
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1980, 312 (03) : 285 - 291
  • [34] SODIUM RETENTION AND HEPATIC-FUNCTION AFTER CARBON-TETRACHLORIDE INDUCED ACUTE LIVER-INJURY IN THE RAT
    WENSING, G
    BRANCH, RA
    HEPATOLOGY, 1989, 10 (04) : 721 - 721
  • [35] Effects of silymarin on the resolution of liver fibrosis induced by carbon tetrachloride in rats
    Tsai, J. H.
    Liu, J. Y.
    Wu, T. T.
    Ho, P. C.
    Huang, C. Y.
    Shyu, J. C.
    Hsieh, Y. S.
    Tsai, C. C.
    Liu, Y. C.
    JOURNAL OF VIRAL HEPATITIS, 2008, 15 (07) : 508 - 514
  • [36] SUSCEPTIBILITY TO CARBON-TETRACHLORIDE INDUCED LIVER TOXICITY IN DEVELOPING RATS
    KISTLER, A
    STEIGER, A
    BUHLER, E
    KELLER, P
    GENERAL PHARMACOLOGY, 1981, 12 (02): : A40 - A40
  • [37] RELATIONSHIPS BETWEEN THE PHARMACOKINETICS OF CARBON-TETRACHLORIDE CONVERSION TO CARBON-DIOXIDE AND CHLOROFORM AND LIVER-INJURY
    REYNOLDS, ES
    TREINEN, RJ
    FARRISH, HH
    MOSLEN, MT
    ARCHIVES OF TOXICOLOGY, 1984, : 303 - 306
  • [38] EFFECTS OF DITHIOCARB AND (+)-CATECHIN AGAINST CARBON-TETRACHLORIDE ALCOHOL-INDUCED LIVER FIBROSIS
    SIEGERS, CP
    VOLPEL, M
    SCHEEL, G
    YOUNES, M
    AGENTS AND ACTIONS, 1982, 12 (5-6): : 743 - 748
  • [39] CARBON-TETRACHLORIDE TOXICITY AS A MODEL FOR STUDYING FREE-RADICAL MEDIATED LIVER-INJURY
    SLATER, TF
    CHEESEMAN, KH
    INGOLD, KU
    PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, 1985, 311 (1152) : 633 - 645
  • [40] STRAIN DIFFERENCES IN MICE IN CARBON TETRACHLORIDE-INDUCED LIVER-INJURY
    BHATHAL, PS
    ROSE, NR
    MACKAY, IR
    WHITTINGHAM, S
    BRITISH JOURNAL OF EXPERIMENTAL PATHOLOGY, 1983, 64 (05): : 524 - 533