EXPRESSION OF THE WILMS-TUMOR GENE (WT1) IN HUMAN LEUKEMIAS

被引：1
|
作者：
MIWA, H
BERAN, M
SAUNDERS, GF
机构：
[1] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT BIOCHEM & MOLEC BIOL,HOUSTON,TX 77030
[2] UNIV TEXAS,MD ANDERSON CANC CTR,DEPT HEMATOL,HOUSTON,TX 77030
来源：
LEUKEMIA | 1992年 / 6卷 / 05期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Leukemic cells from seventy patients with various types of human leukemias were examined for expression of the WT1 gene, the Wilms' tumor gene located at chromosome 11p13. WT1 was expressed in 7 of 16 cases of acute lymphoblastic leukemia, 15 of 22 with acute myelogenous leukemia and 8 of 10 in blast crisis of chronic myelogenous leukemia. No detectable WT1 RNA was found in chronic leukemias, including chronic lymphocytic leukemia, plasma cell leukemia, hairy cell leukemia and chronic myelogenous leukemia in chronic phase. The expression pattern of WT1 in these human leukemia samples indicates the involvement of this gene in the early stage of hematological cell differentiation.
引用
收藏
页码：405 / 409
页数：5
相关论文
共 50 条
  • [41] Altered expression of the WT1 Wilms tumor suppressor gene in human breast cancer
    Silberstein, GB
    VanHorn, K
    Strickland, P
    Roberts, CT
    Daniel, CW
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (15) : 8132 - 8137
  • [42] CELL-TYPES EXPRESSING THE WILMS-TUMOR GENE (WT1) IN WILMS-TUMORS - IMPLICATIONS FOR TUMOR HISTOGENESIS
    PRITCHARDJONES, K
    FLEMING, S
    [J]. ONCOGENE, 1991, 6 (12) : 2211 - 2220
  • [43] Altered expression of the WT1 Wilms tumor suppressor gene in human breast cancer
    Silberstein, G. B.
    Van Horn, K.
    Strickland, P.
    Roberts, C. T.
    [J]. Proceedings of the National Academy of Sciences of the United States of America, 94 (15):
  • [44] wt1 gene expression in childhood leukemias
    Niegemann, E
    Wehner, S
    Kornhuber, B
    Schwabe, D
    Ebener, U
    [J]. ACTA HAEMATOLOGICA, 1999, 102 (02) : 72 - 76
  • [45] INACTIVATION OF WT1 IN NEPHROGENIC RESTS, GENETIC PRECURSORS TO WILMS-TUMOR
    PARK, S
    BERNARD, A
    BOVE, KE
    SENS, DA
    HAZENMARTIN, DJ
    GARVIN, AJ
    HABER, DA
    [J]. NATURE GENETICS, 1993, 5 (04) : 363 - 367
  • [46] Expression of the Wilms' tumor gene (WT1) in normal hemopoiesis - Reply
    Baird, PN
    [J]. EXPERIMENTAL HEMATOLOGY, 1997, 25 (13) : 1312 - 1312
  • [47] THE WILMS-TUMOR GENE WT1 IS EXPRESSED IN MURINE MESODERM-DERIVED TISSUES AND MUTATED IN A HUMAN MESOTHELIOMA
    PARK, S
    SCHALLING, M
    BERNARD, A
    MAHESWARAN, S
    SHIPLEY, GC
    ROBERTS, D
    FLETCHER, J
    SHIPMAN, R
    RHEINWALD, J
    DEMETRI, G
    GRIFFIN, J
    MINDEN, M
    HOUSMAN, DE
    HABER, DA
    [J]. NATURE GENETICS, 1993, 4 (04) : 415 - 420
  • [48] Expression of the Wilms' tumor gene product WT1 in glioblastomas and medulloblastomas
    Nakahara Y.
    Okamoto H.
    Mineta T.
    Tabuchi K.
    [J]. Brain Tumor Pathology, 2004, 21 (3) : 113 - 116
  • [49] Expression of Wilms tumor gene (WT1) in epithelial ovarian cancer
    Hylander, B
    Repasky, E
    Shrikant, P
    Intengan, M
    Beck, A
    Driscoll, D
    Singhal, P
    Lele, S
    Odunsi, K
    [J]. GYNECOLOGIC ONCOLOGY, 2006, 101 (01) : 12 - 17
  • [50] DNA RECOGNITION BY SPLICING VARIANTS OF THE WILMS-TUMOR SUPPRESSOR, WT1
    DRUMMOND, IA
    RUPPRECHT, HD
    ROHWERNUTTER, P
    LOPEZGUISA, JM
    MADDEN, SL
    RAUSCHER, FJ
    SUKHATME, VP
    [J]. MOLECULAR AND CELLULAR BIOLOGY, 1994, 14 (06) : 3800 - 3809
12345