METABOLISM OF 4-(3-CYCLOHEXYLPROPIONYL)-1-(2-ETHOXYPHE PIPERAZINE (D-16120) BY RAT-LIVER MICROSOMES

被引：0
|
作者：
CAPUTO, O [1 ]
ROCCO, F [1 ]
GROSA, G [1 ]
机构：
[1] UNIV TURIN,IST CHIM FARMACEUT APPLICATA,I-10125 TURIN,ITALY
来源：
EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS | 1994年 / 19卷 / 04期
关键词：
4-(3-CYCLOHEXYLPROPIONYL)-1-(2-ETHOXYPHENYL); PIPERAZINE; D-16120; DRUG METABOLISM;
D O I：
10.1007/BF03188856
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The metabolic fate of central analgesic 4-(3-cyclohexylpropionyl)-1-(2-ethoxyphenyl) piperazine (D-16120), was studied in vitro with phenobarbital 3-methylcholanthrene and clofibrate induced rat liver microsomal fractions. The presence of four metabolites was directly or indirectly established. Biotransformation products were isolated by TIC and HPLC techniques and, when possible, the structures were confirmed through comparison with synthetic samples. The metabolic pathways involved are oxidative dealkylation, aromatic and alicyclic hydroxylation.
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页码：303 / 310
页数：8
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