A POLYMORPHISM DETECTED IN A VARIABLE NUMBER OF TANDEM REPEATS (VNTR) OF THE SEMINAL-VESICLE SECRETION (SVS) IV GENE IN INBRED RATS

被引：2
|
作者：
KOBAYASHI, E
IKADAI, H
IMAMICHI, T
KUNIEDA, T
机构：
[1] Imamichi Institute for Animal Reproduction, Ibaraki, 300-01, Fukaya 1103, Dejima-mura, Niihari-gun
来源：
BIOCHEMICAL GENETICS | 1992年 / 30卷 / 7-8期
关键词：
MAMMALIAN GENETICS; RATTUS-NORVEGICUS; SEMINAL VESICLE SECRETION-IV (SVS-IV) GENE; VARIABLE NUMBER OF TANDEM REPEATS (VNTRS); DNA POLYMORPHISM;
D O I：
10.1007/BF00569324
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The second intron of the rat SVS IV gene contains a tandem repeat region of 20-bp sequences. This region was amplified using the polymerase chain reaction to detect variations. Three alleles, characterized by amplified fragments of 750, 490, and 390 bp, respectively, were found in 24 strains examined. This variation segregated in F1 and backcross progeny in an autosomal codominant manner. We tentatively designated this locus Svs-4. Analysis of linkages between the Svs-4 locus and other loci revealed that it was closely linked to the Svp-1 (< 2.9%) and the a (10.0 +/- 6.7%) loci, which belong to rat linkage group IV. The Svp-1 and Svs-4 loci, however, were differently distributed among the inbred rat strains.
引用
收藏
页码：339 / 346
页数：8
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