INSULIN RESISTANCE IN WERNER SYNDROME

被引：9

作者：

OKAMOTO, M ^{[1
]}

YAMADA, K ^{[1
]}

YOSHIMASA, Y ^{[1
]}

KOSAKI, A ^{[1
]}

KONO, S ^{[1
]}

INOUE, G ^{[1
]}

MAEDA, I ^{[1
]}

KUBOTA, M ^{[1
]}

HAYASHI, T ^{[1
]}

KATO, S ^{[1
]}

KUZUYA, H ^{[1
]}

IMURA, H ^{[1
]}

机构：

[1] KYOTO UNIV,SCH MED,DEPT MED,DIV 2,54 KAWAHARACHO,SAKYO KU,KYOTO 606,JAPAN

来源：

MECHANISMS OF AGEING AND DEVELOPMENT | 1992年 / 63卷 / 01期

关键词：

WERNER SYNDROME; INSULIN RESISTANCE; GLUCOSE CLAMP; AGING;

D O I：

10.1016/0047-6374(92)90013-4

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Insulin resistance in Werner's syndrome (WS) was studied using the glucose clamp technique, and compared with physiologically aged and young subjects. Fasting immuno-reactive insulin (IRI) was increased in patients with Werner's syndrome compared with aged and young subjects. Metabolic clearance rate (MCR) of glucose was decreased in the aged and WS. A rightward shift of the dose-response curves of insulin and MCR of glucose was observed in the aged and WS with a more pronounced shift in the latter. MCR of insulin was also decreased in WS. [I-125]insulin binding to erythrocytes was similar in the three groups. These results suggest that insulin resistance associated with WS is due to a post-binding defect manifested by a rightward shift of the dose-response curve of insulin-induced glucose disposal and a decrease in insulin clearance rate.

引用

页码：11 / 25

页数：15

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