A CONCISE ENANTIOSELECTIVE SYNTHESIS OF ALLYLAMINES AND N-BOC-BETA-AMINO ACIDS

被引：40

作者：

ALCON, M ^{[1
]}

CANAS, M ^{[1
]}

POCH, M ^{[1
]}

MOYANO, A ^{[1
]}

PERICAS, MA ^{[1
]}

RIERA, A ^{[1
]}

机构：

[1] UNIV BARCELONA,DEPT QUIM ORGAN,E-08028 BARCELONA,SPAIN

来源：

TETRAHEDRON LETTERS | 1994年 / 35卷 / 10期

关键词：

D O I：

10.1016/S0040-4039(00)76766-9

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A new and efficient enantioseledive synthesis of allylamines and N-Boc-beta-amino acids has been developed. Starting from enantiomerically enriched N-diphenylmethyl-3-amino-1,2-diols, allylamines are easily obtained by a Corey-Hopkins deoxygenative protocol. After a change in the nitrogen protecting group, the resulting N-Boc allylamines are converted into beta-amino acids by hydroboration with 9-BBN followed by oxidation with PDC in DMF.

引用

页码：1589 / 1592

页数：4

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