A CONCISE ENANTIOSELECTIVE SYNTHESIS OF ALLYLAMINES AND N-BOC-BETA-AMINO ACIDS

被引：40
|
作者：
ALCON, M [1 ]
CANAS, M [1 ]
POCH, M [1 ]
MOYANO, A [1 ]
PERICAS, MA [1 ]
RIERA, A [1 ]
机构：
[1] UNIV BARCELONA,DEPT QUIM ORGAN,E-08028 BARCELONA,SPAIN
来源：
TETRAHEDRON LETTERS | 1994年 / 35卷 / 10期
关键词：
D O I：
10.1016/S0040-4039(00)76766-9
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A new and efficient enantioseledive synthesis of allylamines and N-Boc-beta-amino acids has been developed. Starting from enantiomerically enriched N-diphenylmethyl-3-amino-1,2-diols, allylamines are easily obtained by a Corey-Hopkins deoxygenative protocol. After a change in the nitrogen protecting group, the resulting N-Boc allylamines are converted into beta-amino acids by hydroboration with 9-BBN followed by oxidation with PDC in DMF.
引用
收藏
页码：1589 / 1592
页数：4
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