A SPECIFIC PROTEIN FOUND IN HUMAN SENESCENT FIBROBLASTS

被引：0
|
作者：
FAN, QY [1 ]
FRANKEL, HV [1 ]
PRESENT, D [1 ]
WINCHESTER, B [1 ]
机构：
[1] HOSP JOINT DIS & MED CTR,NEW YORK,NY 10003
来源：
CHINESE MEDICAL JOURNAL | 1995年 / 108卷 / 02期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The limited, potential for proliferation of human fibroblasts in culture represents cell level senescence. Aging is a programed process under genetic control, and at certain stage of the life-span of animal cells, some genes start to express. Studying the biomarkers of senescent cells is important to understanding the basic mechanism of aging which may be relevant to the normal cell growth control and tumor biology. A protein with 72 000 Dalton molecular weight was detected by the hybridoma method in our laborotary. The protein shows specificity to senescent or presenescent cells of several cell lines, including WI-38, K.D., U2OS, etc.
引用
收藏
页码：105 / 108
页数：4
相关论文
共 50 条
  • [31] Differential expression of oncogenic miRNAs in proliferating and senescent human fibroblasts
    Wang, Miao
    Cheng, Zhaojie
    Tian, Tian
    Chen, Jingwen
    Dou, Fei
    Guo, Mingzhou
    Cong, Yu-Sheng
    MOLECULAR AND CELLULAR BIOCHEMISTRY, 2011, 352 (1-2) : 271 - 279
  • [32] ALTERED DEGRADATION OF PROTEINS MICROINJECTED INTO SENESCENT HUMAN-FIBROBLASTS
    DICE, JF
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1982, 257 (24) : 4624 - 4627
  • [33] Proteasome response to interferon-γ is altered in senescent human fibroblasts
    Stratford, Fiona L. L.
    Chondrogianni, Niki
    Trougakos, Ioannis P.
    Gonos, Efstathios S.
    Rivett, A. Jennifer
    FEBS LETTERS, 2006, 580 (16) : 3989 - 3994
  • [34] Identification of differentially expressed proteins in senescent human embryonic fibroblasts
    Trougakos, IP
    Saridaki, A
    Panayotou, G
    Gonos, ES
    MECHANISMS OF AGEING AND DEVELOPMENT, 2006, 127 (01) : 88 - 92
  • [35] Promitotic Action of Oenothera biennis on Senescent Human Dermal Fibroblasts
    Ceccacci, Sara
    Roger, Kevin
    Metatla, Ines
    Chhuon, Cerina
    Tighanimine, Khaled
    Fumagalli, Stefano
    De Lucia, Adriana
    Pranke, Iwona
    Cordier, Corinne
    Monti, Maria Chiara
    Guerrera, Ida Chiara
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2022, 23 (23)
  • [36] Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging
    Emma S. Chambers
    Milica Vukmanovic-Stejic
    Barbara B. Shih
    Hugh Trahair
    Priya Subramanian
    Oliver P. Devine
    James Glanville
    Derek Gilroy
    Malcolm H. A. Rustin
    Tom C. Freeman
    Neil A. Mabbott
    Arne N. Akbar
    Nature Aging, 2021, 1 : 101 - 113
  • [37] Human senescent fibroblasts trigger progressive lung fibrosis in mice
    Hernandez-Gonzalez, Fernanda
    Prats, Neus
    Ramponi, Valentina
    Lopez-Dominguez, Jose Alberto
    Meyer, Kathleen
    Aguilera, Monica
    Martin, Maria Isabel Munoz
    Martinez, Daniel
    Agusti, Alvar
    Faner, Rosa
    Sellares, Jacobo
    Pietrocola, Federico
    Serrano, Manuel
    AGING-US, 2023, 15 (14): : 6641 - 6657
  • [38] RESTORATION OF SENESCENT HUMAN DIPLOID FIBROBLASTS BY MODULATION OF THE EXTRACELLULAR MATRIX
    Choi, H.
    Cho, K.
    Park, S.
    GERONTOLOGIST, 2011, 51 : 125 - 125
  • [39] RESUCE OF SENESCENT HUMAN FIBROBLASTS BY HYBRIDIZATION WITH CULTURED HAMSTER CELLS
    GOLDSTEI.S
    LIN, CC
    JOURNAL OF CLINICAL INVESTIGATION, 1971, 50 (06): : A37 - &
  • [40] Ciliary abnormalities in senescent human fibroblasts impair proliferative capacity
    Breslin, Loretta
    Prosser, Suzanna L.
    Cuffe, Sandra
    Morrison, Ciaran G.
    CELL CYCLE, 2014, 13 (17) : 2773 - 2779
12345