Latent Mycobacterium tuberculosis Infection in Liver Transplant Recipients-Controversies in Current Diagnosis and Management

被引：8
|
作者：
Rajagopala, Srinivas [1 ]
Olithselvan, A. [1 ]
Varghese, Joy [1 ]
Shanmugam, Naresh [1 ]
Rela, Mohamed [1 ]
机构：
[1] Global Hosp, Inst Liver Dis & Transplantat, Chennai, Tamil Nadu, India
来源：
JOURNAL OF CLINICAL AND EXPERIMENTAL HEPATOLOGY | 2011年 / 1卷 / 01期
关键词：
Isoniazid prophylaxis; latent tuberculosis infection; liver transplantation; solid organ transplantation; tuberculosis;
D O I：
10.1016/S0973-6883(11)60120-5
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
Liver transplantation for end-stage liver disease is increasingly being undertaken in India. 1 Routine tuberculin skin testing (TST) for latent Mycobacterium tuberculosis infection (LTBI) and isoniazid prophylaxis in TST-positive livertransplant recipients (LTRs) is recommended(2,)3 but seldom implemented worldwide.(4-7) The role of TST-testing and isoniazid prophylaxis in LTRs remains further undefined in high prevalence areas, including India. We describe the burden of LTBI in LTRs; the epidemiological aspects of M. tuberculosis infection in high prevalence areas; identifiable risk factors for M. tuberculosis infection; the limitations of current diagnostic techniques for LTBI in LTRs and the efficacy and toxicity of isoniazid prophylaxis in TST-positive LTRs and suggest directions for future investigations in this area.
引用
收藏
页码：34 / 37
页数：4
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