Main NK cell receptors and their ligands: regulation by microRNAs

被引：7

作者：

Regis, Stefano ^{[1
]}

Caliendo, Fabio ^{[2
]}

Dondero, Alessandra ^{[3
]}

Bellora, Francesca ^{[3
]}

Casu, Beatrice ^{[3
]}

Bottino, Cristina ^{[1
,3
]}

Castriconi, Roberta ^{[3
,4
]}

机构：

[1] Ist Giannina Gaslini, Genoa, Italy

[2] Ist Italiano Tecnol, Ctr Adv Biomat Healthcare, IIT CRIB, Naples, Italy

[3] Univ Genoa, Dipartimento Med Sperimentale, Genoa, Italy

[4] Univ Genoa, Ctr Eccellenza Ric Biomed CEBR, Genoa, Italy

来源：

AIMS ALLERGY AND IMMUNOLOGY | 2018年 / 2卷 / 02期

关键词：

NK cells; microRNAs; NK receptors; NK receptor ligands; TGF-beta; 1;

D O I：

10.3934/Allergy.2018.2.98

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The NK cells functions are finely tuned by several kinds of inhibitory and activating receptors, whose pattern of expression characterizes different NK subpopulations and varies with the cell activation status. MicroRNAs have an important role in tightly regulating the expression of NK receptors and, analogously, the expression of their ligands in target cells. The relevance of the microRNA-mediated control is highlighted by the dysregulation of these pathways observed in cancer and virus-infected cells. Here we review our current knowledge of the microRNAs involved in the regulation of NK receptors, as well as that of the corresponding cellular ligands.

引用

页码：98 / 112

页数：15

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