Psoriasis. Diagnostic and therapeutic recommendations of the Polish Dermatological Society. Part II: Moderate to severe psoriasis

被引：24

作者：

Reich, Adam ^{[1
]}

Szepietowski, Jacek ^{[2
]}

Adamski, Zygmunt ^{[3
]}

Chodorowska, Grazyna ^{[4
]}

Kaszuba, Andrzej ^{[5
]}

Krasowska, Dorota ^{[4
]}

Lesiak, Aleksandra ^{[5
]}

Maj, Joanna ^{[2
]}

Narbutt, Joanna ^{[5
]}

Osmola-Mankowska, Agnieszka ^{[3
]}

Owczarczyk-Saczonek, Agnieszka ^{[6
]}

Owczarek, Witold ^{[7
]}

Placek, Waldemar ^{[6
]}

Rudnicka, Lidia ^{[8
]}

机构：

[1] Univ Rzeszow, Dept Dermatol, Rzeszow, Poland

[2] Wroclaw Med Univ, Dept Dermatol Venereol & Allergol, Wroclaw, Poland

[3] Poznan Univ Med Sci, Dept Dermatol, Poznan, Poland

[4] Med Univ Lublin, Dept Dermatol Venereol & Paediat Dermatol, Lublin, Poland

[5] Wroclaw Med Univ, Dept Dermatol Paediat & Oncol Dermatol, Wroclaw, Poland

[6] Univ Warmia & Mazury, Dept Dermatol Sexually Transmitted Dis & Clin Imm, Olsztyn, Poland

[7] Mil Inst Hlth Serv, Dept Dermatol, Warsaw, Poland

[8] Med Univ Warsaw, Dept Dermatol, Warsaw, Poland

来源：

PRZEGLAD DERMATOLOGICZNY | 2018年 / 105卷 / 03期

关键词：

diagnostics; treatment; psoriasis; guidelines; consensus;

D O I：

10.5114/dr.2018.77107

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

The second part of diagnostic and therapeutic guidelines of Polish Dermatological Society focuses on moderate and severe psoriasis, in which phototherapy or systemic treatment should be initiated. Currently, it is recommended to treat moderate to severe plaque psoriasis with either classic anti-psoriatic drugs (methotrexate, cyclosporine, acitretin), TNF-alpha-inhibitors (adalimumab, etanercept, infliximab), interleukin 12/23 blocking agent (ustekinumab) and new drugs - interleukin-17 inhibitors (secukinumab, ixekizumab) or interleukin 23 inhibitors (guselkumab, tildrakizumab), as well as the new low-molecular weight agents (apremilast, dimethyl fumarate). In some patients, UV-based therapy may be advisable. These recommendations summarize the principles of the use of these agents in patients with psoriasis in dermatological practice. The efficacy and safety of therapy is discussed and available methods to prevent adverse events are summarized.

引用

页码：329 / 357

页数：29

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