RELATIONSHIP BETWEEN STRIATAL GLUCOSE CONSUMPTION AND COPPER EXCRETION IN PATIENTS WITH WILSONS-DISEASE TREATED WITH D-PENICILLAMINE

被引：10
|
作者：
HEFTER, H
KUWERT, T
HERZOG, H
ARENDT, G
STREMMEL, W
FEINENDEGEN, LE
机构：
[1] FORSCHUNGSZENTRUM,INST MED,D-52428 JULICH,GERMANY
[2] UNIV DUSSELDORF,MED KLIN,D-40225 DUSSELDORF,GERMANY
来源：
JOURNAL OF NEUROLOGY | 1993年 / 241卷 / 01期
关键词：
WILSONS DISEASE CEREBRAL GLUCOSE METABOLISM D-PENICILLAMINE; POSITRON EMISSION TOMOGRAPHY;
D O I：
10.1007/BF00870672
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
In 12 patients with Wilson's disease treated with D-penicillamine (DPA), the regional cerebral metabolic rate of glucose consumption of the lentiform and caudate nucleus was analysed using the Fluorodeoxyglucose-18 method and correlated with the clinical symptoms of the patients, the ceruloplasmin level, the serum level of free copper and the 24-h copper excretion. The more copper was eliminated, the higher was the basal ganglia glucose consumption. On the other hand, in seven patients who had been treated for more than 7 years a significant decline of the basal ganglia glucose consumption was observed, suggesting too low a maintenance dose of DPA.
引用
收藏
页码：49 / 53
页数：5
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