SUBSTITUTED THIOPYRANO[2,3,4-C,D]INDOLES AS POTENT, SELECTIVE AND ORALLY-ACTIVE INHIBITORS OF 5-LIPOXYGENASE - DEVELOPMENT AND BIOLOGICAL PROFILE OF L-699,333

被引：0

作者：

THERIEN, M ^{[1
]}

BRIDEAU, C ^{[1
]}

CHAN, C ^{[1
]}

FALGUEYRET, JP ^{[1
]}

GUAY, J ^{[1
]}

JONES, TR ^{[1
]}

LEPINE, C ^{[1
]}

MACDONALD, D ^{[1
]}

MCFARLANE, CS ^{[1
]}

PIECHUTA, H ^{[1
]}

RIENDEAU, D ^{[1
]}

SCHEIGETZ, J ^{[1
]}

TAGARI, P ^{[1
]}

HUTCHINSON, JH ^{[1
]}

GIRARD, Y ^{[1
]}

机构：

[1] MERCK FROSST CTR THERAPEUT RES,POINTE CLAIRE H9R 4P8,PQ,CANADA

来源：

ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY | 1993年 / 206卷

关键词：

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

引用

页码：39 / MEDI

共 8 条

[1] SUBSTITUTED THIOPYRANO[2,3,4-C,D]INDOLES AS POTENT, SELECTIVE, AND ORALLY-ACTIVE INHIBITORS OF 5-LIPOXYGENASE - SYNTHESIS AND BIOLOGICAL EVALUATION OF L-691,816
HUTCHINSON, JH
RIENDEAU, D
BRIDEAU, C
CHAN, C
DELORME, D
DENIS, D
FALGUEYRET, JP
FORTIN, R
GUAY, J
HAMEL, P
JONES, TR
MACDONALD, D
MCFARLANE, CS
PIECHUTA, H
SCHEIGETZ, J
TAGARI, P
THERIEN, M
GIRARD, Y
JOURNAL OF MEDICINAL CHEMISTRY, 1993, 36 (19) : 2771 - 2787
[2] SUBSTITUTED THIOPYRANO[2,3,4-C,D]INDOLES AS POTENT, SELECTIVE AND ORALLY ACTIVE INHIBITORS OF 5-LIPOXYGENASE - DEVELOPMENT OF L-691,816
HUTCHINSON, JH
CHAN, C
DELORME, D
DENIS, D
FALGUEYRET, JP
FORTIN, R
GUAY, J
HAMEL, P
JONES, TR
MACDONALD, D
MCFARLANE, CS
PIECHUTA, H
RIENDEAU, D
SCHEIGETZ, J
TAGARI, P
THERIEN, M
GIRARD, Y
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 205 : 140 - MEDI
[3] SUBSTITUTED THIOPYRANO[2,3,4-C,D]INDOLES AS POTENT, SELECTIVE AND ORALLY ACTIVE INHIBITORS OF 5-LIPOXYGENASE - SYNTHESIS AND SAR STUDIES
MACDONALD, D
HUTCHINSON, JH
DENIS, D
FALGUEYRET, JP
GUAY, J
RIENDEAU, D
SCHEIGETZ, J
THERIEN, M
GIRARD, Y
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 205 : 139 - MEDI
[4] THIOPYRANOL[2,3,4-C,D] INDOLES AS INHIBITORS OF 5-LIPOXYGENASE, 5-LIPOXYGENASE-ACTIVATING PROTEIN, AND LEUKOTRIENE C-4 SYNTHASE
HUTCHINSON, JH
CHARLESON, S
EVANS, JF
FALGUEYRET, JP
HOOGSTEEN, K
JONES, TR
KARGMAN, S
MACDONALD, D
MCFARLANE, CS
NICHOLSON, DW
PIECHUTA, H
RIENDEAU, D
SCHEIGETZ, J
THERIEN, M
GIRARD, Y
JOURNAL OF MEDICINAL CHEMISTRY, 1995, 38 (22) : 4538 - 4547
[5] Substituted (pyridylmethoxy)naphthalenes as potent and orally active 5-lipoxygenase inhibitors: Synthesis, biological profile, and pharmacokinetics of L-739,010
Hamel, P
Riendeau, D
Brideau, C
Chan, CC
Desmarais, S
Delorme, D
Dube, D
Ducharme, Y
Ethier, D
Grimm, E
Falgueyret, JP
Guay, J
Jones, TR
Kwong, E
McAuliffe, M
McFarlane, CS
Piechuta, H
Roumi, M
Tagari, P
Young, RN
Girard, Y
JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (18) : 2866 - 2875
[6] N-3-HETEROARYLSUBSTITUTED-1-METHYL-2-PROPYNYL-N-HYDROXYUREAS, POTENT ORALLY-ACTIVE 2ND-GENERATION 5-LIPOXYGENASE INHIBITORS WITH ENHANCED DURATION OF ACTION
BROOKS, DW
STEWART, AO
BASHA, A
BHATIA, P
RATAJCZYK, JD
CRAIG, R
BELL, RL
BOUSKA, JB
CARTER, GW
ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 1993, 206 : 41 - MEDI
[7] THIOPYRANO[2,3,4-CD]INDOLES AS 5-LIPOXYGENASE INHIBITORS - SYNTHESIS, BIOLOGICAL PROFILE, AND RESOLUTION OF 2-[2-[1-(4-CHLOROBENZYL)-4-METHYL-6-[(5-PHENYLPYRIDIN-2-YL)METHOXY]-4,5-DIHYDRO-1H-THIOPYRANO[2,3,4-CD]INDOL-YL]ETHOXY]BUTANOIC ACID
HUTCHINSON, JH
RIENDEAU, D
BRIDEAU, C
CHAN, C
FALGUEYRET, JP
GUAY, J
JONES, TR
LEPINE, C
MACDONALD, D
MCFARLANE, CS
PIECHUTA, H
SCHEIGETZ, J
TAGARI, P
THERIEN, M
GIRARD, Y
JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (08) : 1153 - 1164
[8] DEVELOPMENT OF 2,3-DIHYDRO-6-(3-PHENOXYPROPYL)-2-(2-PHENYLETHYL)-5-BENZOFURANOL (L-670,630) AS A POTENT AND ORALLY ACTIVE INHIBITOR OF 5-LIPOXYGENASE
LAU, CK
BELANGER, PC
DUFRESNE, C
SCHEIGETZ, J
THERIEN, M
FITZSIMMONS, B
YOUNG, RN
FORDHUTCHINSON, AW
RIENDEAU, D
DENIS, D
GUAY, J
CHARLESON, S
PIECHUTA, H
MCFARLANE, CS
CHIU, SHL
ELINE, D
ALVARO, RF
MIWA, G
WALSH, JL
JOURNAL OF MEDICINAL CHEMISTRY, 1992, 35 (07) : 1299 - 1318

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