THE EFFECTS OF METHOTREXATE ON INTERLEUKIN-1 IN PATIENTS WITH RHEUMATOID-ARTHRITIS

被引：0
|
作者：
CHANG, DM [1 ]
WEINBLATT, ME [1 ]
SCHUR, PH [1 ]
机构：
[1] HARVARD UNIV,BRIGHAM & WOMENS HOSP,SCH MED,DIV RHEUMATOL & IMMUNOL,BOSTON,MA 02115
来源：
JOURNAL OF RHEUMATOLOGY | 1992年 / 19卷 / 11期
关键词：
RHEUMATOID ARTHRITIS; INTERLEUKIN-1; METHOTREXATE;
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The effect of methotrexate (MTX) treatment on patients with rheumatoid arthritis on interleukin 1 (IL-1) was evaluated. Eight patients received a weekly MTX dose of 7.5 mg for 6 weeks; none received concomitant corticosteroids. Peripheral blood was obtained 1 day before and 1 day after their weekly MTX dose at Week 1 and 6, isolated monocytes stimulated ex vivo with 1 mg/ml zymosan for 18 h and IL-1 measured by bioassay. Serum and plasma IL-1 levels were measured by immunoassay. Four patients manifested a sharp decrease in IL-1 production 6 weeks after MTX administration associated with a decrease in the number of painful but not swollen joints. No effect on blood levels was observed. Our results suggest that MTX may affect IL-1 production and IL-1 mediated events in some patients.
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收藏
页码：1678 / 1682
页数：5
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