INHIBITION OF PEROXIDATIONS OF LIPIDS AND MEMBRANES BY ESTROGENS

被引：14

作者：

KOMURO, E ^{[1
]}

TAKAHASHI, M ^{[1
]}

MORITA, T ^{[1
]}

TSUCHIYA, J ^{[1
]}

ARAKAWA, Y ^{[1
]}

YAMAMOTO, Y ^{[1
]}

NIKI, E ^{[1
]}

SUGIOKA, K ^{[1
]}

NAKANO, M ^{[1
]}

机构：

[1] GUNMA UNIV, COLL MED CARE & TECHNOL, MAEBASHI, GUNMA 371, JAPAN

来源：

JOURNAL OF PHYSICAL ORGANIC CHEMISTRY | 1990年 / 3卷 / 05期

关键词：

D O I：

10.1002/poc.610030507

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The antioxidant activity of 2‐hydroxyestradiol was measured quantitatively and compared with those of other estrogens in oxidations of methyl linoleate in homogeneous solution and in aqueous dispersions, oxidations of soybean phosphatidylcholine liposomal membranes and oxidative haemolysis of rabbit erythrocytes, all induced by free radicals generated from a radical initiator. Similar antioxidant activities of estrogens were observed, irrespective of the oxidation system. 2‐Hydroxyestradiol was found to be a potent radical scavenger and its antioxidant activity was close to that of α‐tocopherol, the strongest natural antioxidant. Other phenolic estrogens such as estrone, estriol and β‐estradiol showed a modest antioxidant activity and testosterone did not act as an antioxidant. Copyright © 1990 John Wiley & Sons Ltd.

引用

页码：309 / 315

页数：7

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