DECREASED HEPATOCARCINOGENIC EFFECT OF DIETHYLNITROSAMINE IN EXPERIMENTALLY-INDUCED LIVER-CIRRHOSIS IN RAT - DELAY OR INHIBITION

被引：7
|
作者：
ZALATNAI, A
LAPIS, K
机构：
[1] 1st Institute of Pathology and Experimental Cancer Research, Semmelweis Medical University, H-1085 Budapest
来源：
CANCER LETTERS | 1994年 / 79卷 / 01期
关键词：
LIVER; NEOPLASMS; EXPERIMENTALLY INDUCED; CARBON TETRACHLORIDE; LIVER CIRRHOSIS; ANIMAL MODELS;
D O I：
10.1016/0304-3835(94)90055-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The relationship between CCl4 or (CCl4 + phenobarbital)-induced liver cirrhosis and diethylnitrosamine (DEN) hepatocarinogenesis in male F-344 rats was investigated. DEN given alone produced no liver lesions after 16 weeks, but 4/12 (33%) neoplastic nodules developed when nitrosamine was administered to rats with previously established cirrhosis. On the other hand, (CCl4 + phenobarbital) post-treatment had an even stronger effect, increasing the yield of neoplastic nodules to 100% (28/28). Since the exposure time of DEN was the same in all treated groups (4 months), the results indicate the decreased effectiveness of(CCl4 + phenobarbital) pretreatment on DEN hepatocarcinogenesis.
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页码：1 / 7
页数：7
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