DEVELOPMENT OF CHRONIC SECONDARY EPILEPTIC FOCI FOLLOWING INTRAHIPPOCAMPAL INJECTION OF TETANUS TOXIN IN THE RAT

被引：16
|
作者：
JEFFERYS, JGR
EMPSON, RM
机构：
来源：
EXPERIMENTAL PHYSIOLOGY | 1990年 / 75卷 / 05期
关键词：
D O I：
10.1113/expphysiol.1990.sp003455
中图分类号：
Q4 [生理学];
学科分类号：
071003 ;
摘要：
It is known that injecting a minute dose of tetanus toxin into rat hippocampus leads to a chronic epileptic syndrome. Here we describe the development of secondary, ‘mirror’ epileptic foci in the hippocampus contralateral to a single injection of the toxin (12 mouse LD50). This was detected in slices in vitro prepared 6 to 56 days after injection, both as evoked after‐discharges and as spontaneous synchronous bursts that were mainly restricted to subregions CA3b and c. © 1990 The Physiological Society
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页码：733 / 736
页数：4
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