INTERACTION OF 5-AZACYTIDINE AND DEXAMETHASONE IN THE CONTROL OF HEPATIC TYROSINE AMINOTRANSFERASE

被引：0
|
作者：
SCHULZE, A
BOHME, HJ
GOLTZSCH, W
HOFMANN, E
机构：
[1] Institute of Biochemistry, University of Leipzig School of Medicine
来源：
ADVANCES IN ENZYME REGULATION | 1991年 / 31卷
关键词：
D O I：
10.1016/0065-2571(91)90016-F
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The nucleoside analog 5-azacytidine is able to induce tyrosine aminotransferase several-fold in the liver of suckling rats. Bilateral adrenalectomy abolishes this inducing effect. The drug also decreases significantly the concentration of cytosolic glucocorticoid receptor accompanied by an increase of the glucocorticoid receptor concentration in the nuclei. The antiglucocorticoid RU 486 which abolishes the induction of tyrosine aminotransferase and serine dehydratase by dexamethasone very effectively is not able to inhibit either the induction of tyrosine aminotransferase or the translocation of the glucocorticoid receptor into the nuclei by 5-azacytidine. © 1991.
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页码：247 / 258
页数：12
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