SYNTHESES OF RACEMIC AND OPTICALLY-ACTIVE 4-HYDROXY-2-HYDROXYMETHYL-1,7-DIOXASPIRO[5.5]UNDECANES

被引：0

作者：

KAUGARS, G

NELSON, SJ

DUTTON, FE

MARTIN, SE

机构：

[1] Animal Health Therapeutics, Upjohn Laboratories, The Upjohn Company, Kalamazoo

来源：

SYNTHETIC COMMUNICATIONS | 1993年 / 23卷 / 06期

关键词：

D O I：

10.1080/00397919308009841

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Racemic and optically active 4-hydroxy-2-hydroxymethyl-1,7-dioxaspiro[5.5]undecanes were prepared in six steps from butane-1,2,4-triol and valerolactone with the longest linear sequence being four steps.

引用

页码：797 / 809

页数：13

共 50 条

[31] BIOLOGICAL RECOGNITION OF ENANTIOMERIC SILANES - SYNTHESES AND ANTIMUSCARINIC PROPERTIES OF OPTICALLY-ACTIVE (2-AMINOETHYL)CYCLOHEXYL(HYDROXYMETHYL)PHENYLSILANES AND RELATED QUATERNARY AMMONIUM DERIVATIVES
TACKE, R
REICHEL, D
KROPFGANS, M
JONES, PG
MUTSCHLER, E
GROSS, J
HOU, X
WAELBROECK, M
LAMBRECHT, G
ORGANOMETALLICS, 1995, 14 (01) : 251 - 262
[32] CHIRAL BUILDING UNITS FROM CARBOHYDRATES .9. SYNTHESIS OF ENANTIOMERIC 2,8-DIMETHYL-1,7-DIOXASPIRO[5.5]UNDECAN-4-OLS, COMPONENTS FROM THE PHEROMONE BOUQUET OF ANDRENA-WILKELLA
REDLICH, H
SCHNEIDER, B
LIEBIGS ANNALEN DER CHEMIE, 1983, (03): : 412 - 424
[33] MICROBIAL-PRODUCTION OF OPTICALLY-ACTIVE 1,3-BUTANEDIOL FROM 4-HYDROXY-2-BUTANONE
MATSUYAMA, A
KOBAYASHI, Y
OHNISHI, H
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY, 1993, 57 (02) : 348 - 349
[34] RACEMIC AND OPTICALLY-ACTIVE POLY(4-METHYL-2-OXO-2-HYDRO-1,3,2-DIOXAPHOSPHOLANE) - SYNTHESIS AND OXIDATION TO THE POLYACIDS
BIELA, T
PENCZEK, S
SLOMKOWSKI, S
VOGL, O
MAKROMOLEKULARE CHEMIE-RAPID COMMUNICATIONS, 1982, 3 (10): : 667 - 671
[35] Syntheses of both enantiomers of 1,7-dioxaspiro[5.5]undecane:: Pheromone components of the olive fruit-fly Dacus oleae from a new chiral intermediate, the (Ss)-2-(p-tolylsulfinyl)prop-2-en-1-ol
Hayes, P
Maignan, C
SYNTHESIS-STUTTGART, 1999, (05): : 783 - 786
[36] STEREOSPECIFIC 1,2-ARYL MIGRATION IN 2-HYDROXY ALKYL ARYL ACETALS WITH PPH3/CCL4 - SYNTHESES OF OPTICALLY-ACTIVE IBUPROFEN AND NAPROXEN
SONAWANE, HR
NANJUNDIAH, BS
KULKARNI, DG
AHUJA, JR
TETRAHEDRON-ASYMMETRY, 1991, 2 (04) : 251 - 252
[37] A NITRILE OXIDE BASED ENTRY TO 2,3-DIHYDROPYRAN-4-ONES - SYNTHESIS OF A PROTECTED VERSION OF COMPACTIN LACTONE IN RACEMIC AND OPTICALLY-ACTIVE FORMS
KOZIKOWSKI, AP
LI, CS
JOURNAL OF ORGANIC CHEMISTRY, 1985, 50 (06): : 778 - 785
[38] SYNTHESES AND CD STUDIES OF OPTICALLY-ACTIVE SUBSTITUTED 1,3,4,5-TETRAHYDRO-2H-1,5-BENZODIAZEPIN-2-ONES
MALIK, F
HASAN, M
KHAN, KM
PERVEEN, S
SNATZKE, G
DUDDECK, H
VOELTER, W
LIEBIGS ANNALEN, 1995, (10): : 1861 - 1869
[39] SYNTHESIS OF SPIROACETALS USING ORGANOSELENIUM-MEDIATED CYCLIZATION REACTIONS - X-RAY MOLECULAR-STRUCTURE OF (2S,8R)-8-METHYL-2-PHENYL-1,7-DIOXASPIRO[5.5]UNDECAN-4(R)-OL
DOHERTY, AM
LEY, SV
LYGO, B
WILLIAMS, DJ
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1, 1984, (06): : 1371 - 1377
[40] ENZYMATIC RESOLUTION OF 2-ACYL-3-HYDROXYMETHYL-4-BUTANOLIDE AND PREPARATION OF OPTICALLY-ACTIVE IM-2, THE AUTOREGULATOR FROM STREPTOMYCES SP FRI-5
MIZUNO, K
SAKUDA, S
NIHIRA, T
YAMADA, Y
TETRAHEDRON, 1994, 50 (37) : 10849 - 10858

← 1 2 3 4 5 →