A polymorphism associated with increased levels of YKL-40 and the risk of early onset of lone atrial fibrillation

被引：4
|
作者：
Henningsen, Kristoffer [1 ,2 ]
Olesen, Morten [1 ,2 ]
Sajadieh, Golnaz [1 ,2 ]
Haunsoe, Stig [1 ,2 ,3 ]
Svendsen, Jesper [1 ,2 ,3 ]
机构：
[1] Univ Copenhagen, Heart Ctr, Dept Cardiol, Rigshosp, Copenhagen, Denmark
[2] Danish Natl Res Fdn, Ctr Cardiac Arrhythmia DARC, Copenhagen, Denmark
[3] Univ Copenhagen, Fac Hlth Sci, Dept Surg & Med, Copenhagen, Denmark
来源：
JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE | 2013年 / 12卷
关键词：
YKL-40; Single nucleotide polymorphism; Inflammation; Atrial fibrillation;
D O I：
10.1186/1477-5751-12-1
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Background: Plasma levels of YKL-40 are elevated in patients with atrial fibrillation (AF). We hypothesized that a single nucleotide polymorphism (SNP) that affects YKL-40 plasma levels is associated to the risk of lone AF. Findings: We included 178 young patients with lone AF and the first episode before the age of 40 years, and a control group of 875 healthy individuals. We analyzed a promoter SNP (-131CG) (rs4950928) in the Chitinase 3-like 1 (CHI3L1) gene encoding YKL-40, which had previously been associated with elevated levels of YKL-40. Conclusions: The (-131CG) genotype was not associated with increased risk of AF. Genetically increased YKL-40 levels were not associated to AF.
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页数：2
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