SYNTHESIS AND EVALUATION OF N-SUBSTITUTED 1-(5-FLUORO-2-PYRIMIDINYL)PIPERAZINE DERIVATIVES AS POTENTIAL ANTIISCHEMIC AGENTS

被引：1
|
作者：
YEVICH, JP
DEXTRAZE, P
TAYLOR, DP
MOON, SL
机构：
[1] Bristol-Meyers Squibb Pharmaceutical Research Institute, Wallingford, CT 06492-7660
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 16期
关键词：
D O I：
10.1016/S0960-894X(01)80539-4
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
A number of N-substituted 1-(5-fluoro-2-pyrimidinyl)piperazine derivatives were prepared and evaluated for binding to sigma and serotonin 5-HT1A and 5-HT2 receptor subtypes as well as for their protection against nitrogen anoxia-induced lethality in rats. Although various compounds exhibited good binding affinity and/or anti-anoxic effects, there was no obvious correlation between their receptor binding and in vivo effects.
引用
收藏
页码：1941 / 1946
页数：6
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