Evaluation of biochemical parameters for assessment of fracture healing in dogs

Biochemical parameters like C-reactive protein and alkaline phosphatase were evaluated during fracture healing in 12 dogs with tibial diaphyseal fractures, which were stabilized with linear external skeletal fixator using light weight, radiolucent carbon connecting rods. Statistical analysis revealed a highly significant difference (P<0.01) in serum alkaline phosphatase and C-reactive protein values in different stages of postoperative intervals. The serum alkaline phosphatase values significantly increased from 0th day to 14th day and thereafter reached to normal values by 21st postoperative day. Lower C-reactive protein values were observed in cases stabilized by closed reduction than in fractures that subjects to open reduction and the values decreased by 3 weeks. Fixator complete removal was done on an average 4-7weeks.