THE EXCRETION OF URINARY GLYCOSAMINOGLYCANS BY FLUOROTIC RATS

This study describes differences in excretion of sulphated glycoproteins, including glycosaminoglycans and possibly Tam-Horsfall like proteins, in the urine of fluorotic and control rats. Changes in molecular size of protein and covalently bound radiosulphate profiles together with differences in Alcian blue and Ponceau S staining of the electrophoretically separated molecular size fractions were evident in fluorotic urines. The findings highlight changes in connective tissues in fluorosis which manifest themselves as urinary metabolites.