PREDICTED AMINO-ACID-SEQUENCE AND GENOMIC ORGANIZATION OF TRYPANOSOMA-CRUZI HSP-60 GENES

被引：15

作者：

GIAMBIAGIDEMARVAL, M

GOTTESDIENER, K

RONDINELLI, E

VANDERPLOEG, LHT

机构：

[1] UNIV FED RIO DE JANEIRO, CCS, INST BIOFIS CARLOS CHAGAS FILHO, BLOCO G, BR-21949 RIO DE JANEIRO, BRAZIL

[2] COLUMBIA UNIV COLL PHYS & SURG, DEPT GENET & DEV, NEW YORK, NY 10032 USA

[3] COLUMBIA UNIV COLL PHYS & SURG, DEPT MED, NEW YORK, NY 10032 USA

来源：

MOLECULAR AND BIOCHEMICAL PARASITOLOGY | 1993年 / 58卷 / 01期

关键词：

TRYPANOSOMA-CRUZI; HSP-60; HEAT SHOCK PROTEIN;

D O I：

10.1016/0166-6851(93)90087-E

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We describe the isolation of a Trypanosoma cruzi protein-coding gene that exhibited about 50% identity with members of the family of heat shock protein (hsp) 60 genes. Since this homology extended for most of the predicted 562 amino acid open reading frame and was comparable to the level of sequence identity between the individual hsp 60 genes from diverged species, we conclude that we have isolated and characterized a T. cruzi hsp 60 gene. The T. cruzi hsp 60 genes are arranged in tandem arrays, and the presence of restriction fragment length polymorphisms (RFLPs) among the different hsp 60 genes suggests the presence of several separate gene arrays encoding hsp 60 members.

引用

页码：25 / 31

页数：7

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