ASSESSMENT OF IODOHEXADECENOIC ACID AS A TRACER OF FATTY-ACID METABOLISM BY EXTERNAL DETECTION - A STUDY ON ISOLATED RAT-HEART

被引：2
|
作者：
KERIEL, CM
DUBOIS, FM
BATLLE, DSM
PERNIN, CR
LEVERVE, XM
MATHIEU, JP
COMET, M
CUCHET, PJ
机构：
[1] UNIV GRENOBLE 1,ETUD RADIOPHARMACEUT LAB,F-38041 GRENOBLE,FRANCE
[2] UNIV GRENOBLE 1,THERAPEUT LAB,F-38041 GRENOBLE,FRANCE
来源：
NUCLEAR MEDICINE AND BIOLOGY | 1992年 / 19卷 / 03期
关键词：
D O I：
10.1016/0883-2897(92)90120-N
中图分类号：
R8 [特种医学]; R445 [影像诊断学];
学科分类号：
1002 ; 100207 ; 1009 ;
摘要：
Labelled fatty acids have been proposed to explore cardiac metabolism. For the analysis of the external detection curve obtained with 16-iodo 9-hexadecenoic acid (IHA), we developed a mathematical 4-compartment model with compartments 0, 1, 2 and 3 representing vascular IHA, intracellular IHA, esterified forms and iodide, respectively. This model, used here for isolated rat hearts perfused in a recirculating system, is validated by an intracellular analysis, then tested in various metabolic conditions. Thus, the mathematical analysis of the external detection curve gives us numerical data on IHA metabolism, especially the distribution between degradation and storage. Our results confirm the suitability of IHA for assessing myocardial metabolism.
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页码：349 / 355
页数：7
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