A SACCHAROMYCES-CEREVISIAE CYCLOPHILIN RESIDENT IN THE ENDOPLASMIC-RETICULUM

被引：35
|
作者：
FRIGERIO, G
PELHAM, HRB
机构：
[1] Division of Cell Biology, MRC Laboratory of Molecular Biology, Cambridge CB2 2QH, Hills Road
来源：
JOURNAL OF MOLECULAR BIOLOGY | 1993年 / 233卷 / 01期
关键词：
CYCLOPHILIN; PROLINE ISOMERASE; SACCHAROMYCES-CEREVISIAE; ER LOCALIZATION; HDEL-PROTEIN;
D O I：
10.1006/jmbi.1993.1497
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Cyclophilins are cyclosporin A sensitive peptidyl-prolyl cis-trans isomerases found in the cytoplasm of a wide range of species from Escherichia coli to man. Cyclophilin homologues are translocated into mitochondria, the endoplasmic reticulum and the bacterial periplasmic space. Here, the nucleotide sequence of a non-essential fifth Saccharomyces cerevisiae cyclophilin homologue encoded by chromosome XII is presented. As expected from its hydrophobic signal sequence and a hydrophilic carboxy terminus ending in the tetrapeptide HDEL, epitope-tagged cyclophilin D was found associated with the endoplasmic reticulum. © 1993 Academic Press Limited.
引用
收藏
页码：183 / 188
页数：6
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