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Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Key Lab Rheumatol & Clin Immunol,Natl Clin Res Ct, Minist Educ,Dept Rheumatol & Clin Immunol, Beijing, Peoples R China Chinese Acad Med Sci & Peking Union Med Coll, Peking Union Med Coll Hosp, Key Lab Rheumatol & Clin Immunol,Natl Clin Res Ct, Minist Educ,Dept Rheumatol & Clin Immunol, Beijing, Peoples R China