Large-Cell Neuroendocrine Carcinoma of the Lung: An Aggressive Neuroendocrine Lung Cancer

被引:35
|
作者
Fernandez, Felix G. [1 ]
Battafarano, Richard J. [1 ]
机构
[1] Washington Univ, Sch Med, Dept Surg, Div Cardiothorac Surg, St Louis, MO USA
关键词
neuroendocrine spectrum; pulmonary tumors; large cell neuroendocrine carcinoma; non-small cell lung cancer;
D O I
10.1053/j.semtcvs.2006.08.007
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Large cell neuroendocrine carcinoma (LCNEC) is part of the neuroendocrine spectrum of pulmonary tumors. This increasingly recognized tumor has been reported to have 5-year actuarial survival rates following resection that are worse than those described for other variants of non-small cell lung cancer (NSCLC). Therefore, debate has emerged regarding whether the tumors should be classified and treated as NSCLC or small-cell lung cancer. This article reviews the tumor characterization, biology, presentation and diagnosis, surgical therapy, results of therapy, and long term prognosis of patients with LCNEC. © 2006 Elsevier Inc. All rights reserved.
引用
收藏
页码:206 / 210
页数:5
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