THE FREQUENCY OF MOUSE SPLEEN DENDRITIC CELLS WHICH PRESENT ALLOANTIGENS OR OVALBUMIN TO PRIMED LYMPHOCYTE-T IS EQUAL

被引：1
|
作者：
GOODACRE, JA [1 ]
JOHNSTONE, R [1 ]
ATHERTON, MC [1 ]
ROBINSON, JH [1 ]
机构：
[1] NEWCASTLE UNIV, SCH PATHOL SCI, DIV IMMUNOL, Newcastle Upon Tyne, Tyne & Wear, ENGLAND
来源：
CELLULAR IMMUNOLOGY | 1990年 / 126卷 / 02期
基金：
英国医学研究理事会;
关键词：
D O I：
10.1016/0008-8749(90)90331-K
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
We have used limiting dilution analysis to compare the frequency of dendritic cells (DC) which present endogenous alloantigens with that which present an exogenous protein antigen to T lymphocytes. Spleen DC present alloantigens or ovalbumin to primed T lymphocytes with equal frequency, showing that DC are equipotent for presenting endogenous and exogenous antigens. Also, antigen-presenting cell (APC) frequencies among DC were compared with other APC populations. DC were enriched about 1000-fold for APC compared to unfractionated spleen cells. © 1990.
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页码：406 / 413
页数：8
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