STRUCTURAL PECULIARITIES OF THE ERYTHROCYTE SURFACE IN HEMOLYTIC-DISEASE OF NEWBORNS

Assessment of structural state of the erythrocyte (Er) surface was done in accordance with the capability of overmembranous glycoproteins and glycolipids of sorbing the vital stain Alcain blue (AB). The extent of AB sorbing by the Er surface of healthy infants is nearly 5.51 . 10(-13) g per cell, whereas in children with hemolytic disease of newborns (HDN) under average grave condition, and in children with HDN and concomitant diseases this index is seen to reduce significantly down to 82.4 and 70.8 per cent, respectively, which may be due presumably to the masking of glycocalyx with Er antibodies. A tendency to the same change appears in hyperbilirubinemia of vague etiology. There as a true increase in AB sorbing with the grave form of HDN (up to 121.8%). This is perphaps because of the increase in Er external membrane permeability to stain and because of the increased sorbing of the stain by intracellular components.