DIHYDROFOLATE-REDUCTASE (DHFR) GENE AMPLIFICATION IN ACUTE LYMPHOBLASTIC-LEUKEMIA (ALL) BLASTS RESISTANT TO METHOTREXATE (MTX) IS ASSOCIATED WITH MUTATIONS IN THE P53 GENE

被引：0
|
作者：
GOKER, E [1 ]
KHERADPOUR, A [1 ]
TRIPPETT, T [1 ]
WALTHAM, M [1 ]
ELISSEYEFF, Y [1 ]
SCHNIEDERS, B [1 ]
BERTINO, JR [1 ]
机构：
[1] MEM SLOAN KETTERING CANC CTR,NEW YORK,NY 10021
来源：
BLOOD | 1993年 / 82卷 / 10期
关键词：
D O I：
暂无
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
引用
收藏
页码：A38 / A38
页数：1
相关论文
共 50 条
  • [41] MUTATIONS OF THE P53 GENE ARE ASSOCIATED WITH GENETIC INSTABILITY AND IMMORTALIZATION IN MYELOGENOUS LEUKEMIA
    ZHANG, W
    CORK, A
    TRUJILLO, J
    CALVERT, L
    HU, GY
    ANDERSSON, B
    DEISSEROTH, AB
    CANCER RESEARCH THERAPY & CONTROL, 1993, 3 (02): : 139 - 144
  • [42] p53 gene status and chemosensitivity of childhood acute lymphoblastic leukemia cells to adriamycin
    Lam, VT
    McPherson, JP
    Salmena, L
    Lees, J
    Chu, W
    Sexsmith, E
    Hedley, DW
    Freedman, MH
    Reed, JC
    Malkin, D
    Goldenberg, GJ
    LEUKEMIA RESEARCH, 1999, 23 (10) : 871 - 880
  • [43] DIHYDROFOLATE-REDUCTASE GENE AMPLIFICATION AND POSSIBLE REARRANGEMENT IN ESTROGEN-RESPONSIVE METHOTREXATE-RESISTANT HUMAN-BREAST CANCER-CELLS
    COWAN, KH
    GOLDSMITH, ME
    LEVINE, RM
    AITKEN, SC
    DOUGLASS, E
    CLENDENINN, N
    NIENHUIS, AW
    LIPPMAN, ME
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1982, 257 (24) : 5079 - 5086
  • [44] POINT MUTATIONS IN THE CONSERVED REGIONS OF THE P53 TUMOR SUPPRESSOR GENE DO NOT ACCOUNT FOR THE TRANSFORMING PROCESS IN THE JURKAT ACUTE LYMPHOBLASTIC-LEUKEMIA T-CELLS
    LAUMANN, R
    JUCKER, M
    TESCH, H
    LEUKEMIA, 1992, 6 (03) : 227 - 228
  • [45] Inactivation of p53 and amplification of MYCN gene in a terminal lymphoblastic relapse in a chronic lymphocytic leukemia patient
    Stano-Kozubik, Katerina
    Malcikova, Jitka
    Tichy, Boris
    Kotaskova, Jana
    Borsky, Marek
    Hrabcakova, Viera
    Francova, Hana
    Valaskova, Iveta
    Bourkova, Ludmila
    Smardova, Jana
    Doubek, Michael
    Brychtova, Yvona
    Pospisilova, Sarka
    Mayer, Jiri
    Trbusek, Martin
    CANCER GENETICS AND CYTOGENETICS, 2009, 189 (01) : 53 - 58
  • [46] Prognostic significance of the tumor suppressor protein p53 gene in childhood acute lymphoblastic leukemia
    Weng, Wenwen
    Zhang, Ping
    Ruan, Jinfei
    Zhang, Yao
    Ba, Diandian
    Tang, Yongmin
    ONCOLOGY LETTERS, 2020, 19 (01) : 549 - 556
  • [47] P53 GENE-MUTATIONS IN ACUTE MYELOID-LEUKEMIA WITH 17P MONOSOMY
    FENAUX, P
    JONVEAUX, P
    QUIQUANDON, I
    LAI, JL
    PIGNON, JM
    LOUCHEUXLEFEBVRE, MH
    BAUTERS, F
    BERGER, R
    KERCKAERT, JP
    BLOOD, 1991, 78 (07) : 1652 - 1657
  • [48] Microsatellite instability and p53 mutations are associated with abnormal expression of the MSH2 gene in adult acute leukemia
    Zhu, YM
    Das-Gupta, EP
    Russell, NH
    BLOOD, 1999, 94 (02) : 733 - 740
  • [49] MODULATION OF DIHYDROFOLATE (DHFR) AND MULTIDRUG RESISTANCE (MDR-1/P-170) GENES AS MECHANISMS OF CLINICAL DRUG-RESISTANCE IN PATIENTS WITH ACUTE LYMPHOBLASTIC-LEUKEMIA (ALL)
    ROTHENBERG, ML
    MICKLEY, LA
    FOJO, AT
    COLE, D
    BALIS, FM
    HAMILTON, TC
    OZOLS, RF
    POPLACK, DG
    PROCEEDINGS OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 1988, 29 : 304 - 304
  • [50] Prognostic value of p53 gene mutations and the product expression in de novo acute myeloid leukemia
    Nakano, Y
    Naoe, T
    Kiyoi, H
    Kitamura, K
    Minami, S
    Miyawaki, S
    Asou, N
    Kuriyama, K
    Kusumoto, S
    Shimazaki, C
    Akiyama, H
    Saito, K
    Nishimura, M
    Motoji, T
    Shinagawa, K
    Saito, H
    Ohno, R
    EUROPEAN JOURNAL OF HAEMATOLOGY, 2000, 65 (01) : 23 - 31
12345