FACILE SYNTHESIS OF NOVEL SPIRO[AZETIDINE-2,4'(1'H)-ISOQUINOLINE-1',3',4(2'H)-TRIONES]

被引：10
|
作者：
MALAMAS, MS
机构：
[1] Department of Medicinal Chemistry, Wyeth‐Ayerst Research, Inc, Princeton, New Jersey
来源：
JOURNAL OF HETEROCYCLIC CHEMISTRY | 1994年 / 31卷 / 02期
关键词：
D O I：
10.1002/jhet.5570310254
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A convenient general method for the synthesis of a new heterocycle, spiro[azetidine-2,4'(1'H)-isoquinoline-1',3',4(2'H)-trione] is described. The key intermediate 2 was prepared by direct halogenation of position-4 of acid 3 with thionyl chloride, and subsequent treatment of the generated 4-Cl, 4-acetyl chloride 11 with a THF/NH3 solution at low temperature.
引用
收藏
页码：565 / 568
页数：4
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