FACILE SYNTHESIS OF NOVEL SPIRO[AZETIDINE-2,4'(1'H)-ISOQUINOLINE-1',3',4(2'H)-TRIONES]

被引：10

作者：

MALAMAS, MS

机构：

[1] Department of Medicinal Chemistry, Wyeth‐Ayerst Research, Inc, Princeton, New Jersey

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1994年 / 31卷 / 02期

关键词：

D O I：

10.1002/jhet.5570310254

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient general method for the synthesis of a new heterocycle, spiro[azetidine-2,4'(1'H)-isoquinoline-1',3',4(2'H)-trione] is described. The key intermediate 2 was prepared by direct halogenation of position-4 of acid 3 with thionyl chloride, and subsequent treatment of the generated 4-Cl, 4-acetyl chloride 11 with a THF/NH3 solution at low temperature.

引用

页码：565 / 568

页数：4

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