PARTIAL DOPAMINE AGONIST THERAPY OF LEVODOPA-INDUCED DYSKINESIAS

被引：47

作者：

BARONTI, F ^{[1
]}

MOURADIAN, MM ^{[1
]}

CONANT, KE ^{[1
]}

GIUFFRA, M ^{[1
]}

BRUGHITTA, G ^{[1
]}

CHASE, TN ^{[1
]}

机构：

[1] NINCDS,EXPTL THERAPEUT BRANCH,BLDG 10,ROOM 5C103,BETHESDA,MD 20892

来源：

NEUROLOGY | 1992年 / 42卷 / 06期

关键词：

D O I：

10.1212/WNL.42.6.1241

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

We administered the partial dopamine agonist terguride under controlled conditions to patients with Parkinson's disease (PD), both as monotherapy and in conjunction with intravenous levodopa. Terguride produced a dose-dependent decrease in levodopa-induced dyskinesias (up to 53%) in seven patients without concomitant worsening of parkinsonism, and had no significant antiparkinsonian effect when administered alone. Partial dopamine agonists may hold some promise in the adjuvant therapy of patients with advanced PD.

引用

页码：1241 / 1243

页数：3

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