THERMOREGULATION AND HYPOTHALAMIC HISTAMINE TURNOVER MODULATED BY INTERLEUKIN-1-BETA IN RATS

被引：10
|
作者：
KANG, M [1 ]
YOSHIMATSU, H [1 ]
OGAWA, R [1 ]
KUROKAWA, M [1 ]
OOHARA, A [1 ]
TAMARI, Y [1 ]
SAKATA, T [1 ]
机构：
[1] OITA MED UNIV,SCH MED,DEPT INTERNAL MED 1,OITA 87955,JAPAN
来源：
BRAIN RESEARCH BULLETIN | 1994年 / 35卷 / 04期
关键词：
HYPOTHALAMIC HISTAMINE TURNOVER; INTERLEUKIN-1-BETA; HIGH AMBIENT TEMPERATURE; RECTAL TEMPERATURE;
D O I：
10.1016/0361-9230(94)90105-8
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
To clarify the involvement of hypothalamic histamine in thermogenic response provoked by high ambient temperature, or interleukin-1 beta (IL-1 beta), changes in rectal temperature and histamine turnover were investigated. Rectal temperature was maintained normally after exposure to high ambient temperature, but elevated by IL-1 beta. In spite of these different responses of body temperature, hypothalamic histamine turnover was increased in each treatment. The results suggest that hypothalamic histaminergic neurons are activated not only peripherally by high ambient temperature, but also centrally by IL-1 beta as endogenous pyrogen.
引用
收藏
页码：299 / 301
页数：3
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