PARTIAL PROTECTIVE EFFECT OF MK-801 ON MPTP-INDUCED REDUCTION OF STRIATAL DOPAMINE IN MICE

被引：45

作者：

TABATABAEI, A ^{[1
]}

PERRY, TL ^{[1
]}

HANSEN, S ^{[1
]}

KRIEGER, C ^{[1
]}

机构：

[1] UNIV BRITISH COLUMBIA,DEPT PHARMACOL & THERAPEUT,VANCOUVER V6T 1W5,BC,CANADA

来源：

NEUROSCIENCE LETTERS | 1992年 / 141卷 / 02期

基金：

英国医学研究理事会;

关键词：

MK-801; MPTP; EXCITATORY AMINO ACID; DOPAMINE; PARKINSONISM;

D O I：

10.1016/0304-3940(92)90892-B

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The protective effect of MK-80 1, an N-methyl-D-aspartate (NMDA) receptor antagonist on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced reduction of striatal dopamine (DA) was examined in C57 BL/6 mice. Striatal DA levels were significantly higher in animals receiving parenteral MK-801 before and for 48 h following MPTP administration after 28 days than in animals receiving MPTP alone. The effect was not due to inhibition of monoamine oxidase-B (MAO-B) by MK-801. These data suggest that NMDA receptors may be involved in some of the neurotoxicity produced by MPTP.

引用

页码：192 / 194

页数：3

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