PARTIAL PROTECTIVE EFFECT OF MK-801 ON MPTP-INDUCED REDUCTION OF STRIATAL DOPAMINE IN MICE

被引：45
|
作者：
TABATABAEI, A [1 ]
PERRY, TL [1 ]
HANSEN, S [1 ]
KRIEGER, C [1 ]
机构：
[1] UNIV BRITISH COLUMBIA,DEPT PHARMACOL & THERAPEUT,VANCOUVER V6T 1W5,BC,CANADA
来源：
NEUROSCIENCE LETTERS | 1992年 / 141卷 / 02期
基金：
英国医学研究理事会;
关键词：
MK-801; MPTP; EXCITATORY AMINO ACID; DOPAMINE; PARKINSONISM;
D O I：
10.1016/0304-3940(92)90892-B
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
The protective effect of MK-80 1, an N-methyl-D-aspartate (NMDA) receptor antagonist on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced reduction of striatal dopamine (DA) was examined in C57 BL/6 mice. Striatal DA levels were significantly higher in animals receiving parenteral MK-801 before and for 48 h following MPTP administration after 28 days than in animals receiving MPTP alone. The effect was not due to inhibition of monoamine oxidase-B (MAO-B) by MK-801. These data suggest that NMDA receptors may be involved in some of the neurotoxicity produced by MPTP.
引用
收藏
页码：192 / 194
页数：3
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