THROMBIN - STRUCTURE-FUNCTION-RELATIONSHIPS IN BIOCHEMICAL INTERACTIONS

被引：0
|
作者：
MAKSIMENKO, AV
机构：
来源：
BIOCHEMISTRY-MOSCOW | 1993年 / 58卷 / 09期
关键词：
THROMBIN; ANION-BINDING EXOSITE; PLATELET THROMBIN RECEPTOR; THROMBOMODULIN; FIBRINOGEN; THROMBOSIS; TARGETED DRUGS; ENZYME CONJUNCTIVE THERAPY;
D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Data on the content and localization of the recognition site (exosite) of high-molecular-weight substrates in the thrombin molecule are summarized This site, which binds anionic regions of macromolecules, is shown to be involved in the regulation of thrombin activity. Data on the proteolytic mechanism of platelet receptor activation by thrombin are reported Prospects of biomedical studies of thrombin derivatives as new therapeutic agents and combined courses of thrombolytic therapy as well as possibilities for developing a computer model of thrombin interactions for theoretical and applied purposes are discussed
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页码：993 / 1000
页数：8
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