Protein target discovery of drug and its reactive intermediate metabolite by using proteomic strategy

被引：8

作者：

Hu, Lianghai ^{[1
,2
]}

Fawcett, John Paul ^{[3
]}

Gu, Jingkai ^{[1
,2
]}

机构：

[1] Jilin Univ, Norman Bethune Hosp 1, Inst Translat Med, Clin Pharmacol Ctr, Changchun 130021, Jilin, Peoples R China

[2] Jilin Univ, Coll Life Sci, Res Ctr Drug Metab, Changchun 130023, Jilin, Peoples R China

[3] Univ Otago, Sch Pharm, Dunedin, New Zealand

来源：

ACTA PHARMACEUTICA SINICA B | 2012年 / 2卷 / 02期

关键词：

Drug target; Reactive metabolite; Proteomics; Mass spectrometry;

D O I：

10.1016/j.apsb.2012.02.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Identifying protein targets of bioactive compounds is an effective approach to discover unknown protein functions, identify molecular mechanisms of drug action, and obtain information for optimization of lead compounds. At the same time, metabolic activation of a drug can lead to cytotoxicities. Therefore, it is very important to systemically characterize the drug and its reactive intermediate. Mass spectrometry-based proteomic approach has emerged as the most efficient to study protein functions and modifications. This review will discuss method development for the drug target discovery and the application in different fields including the drug toxicity mechanism caused by reactive metabolites. (C) 2012 Institute of Materia Medica, Chinese Academy of Medical Sciences and Chinese Pharmaceutical Association. Production and hosting by Elsevier B.V. All rights reserved.

引用

页码：126 / 136

页数：11

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