LIPID MODULATION OF NICOTINIC ACETYLCHOLINE-RECEPTOR FUNCTION - THE ROLE OF MEMBRANE LIPID-COMPOSITION AND FLUIDITY

被引：102

作者：

SUNSHINE, C ^{[1
]}

MCNAMEE, MG ^{[1
]}

机构：

[1] UNIV CALIF DAVIS,MOLEC & CELLULAR BIOL SECT,DAVIS,CA 95461

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 1994年 / 1191卷 / 01期

关键词：

NICOTINIC ACETYLCHOLINE RECEPTOR; MEMBRANE FLUIDITY; LIPID COMPOSITION; ION CHANNEL FUNCTION;

D O I：

10.1016/0005-2736(94)90233-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The effects of membrane lipid composition and fluidity on AChR ion channel function were studied after reconstituting the receptor with sphingomyelin, phosphatidylcholines with different degrees of unsaturation, or different neutral lipids. AChR ion flux activity was shown to be retained in some membranes of both high and low fluidity, as measured by the steady-state anisotropy of the membrane probes diphenylhexatriene and trimethylammonium diphenylhexatriene. The results suggest that lipid composition is more important than bulk membrane fluidity in determining AChR ion channel function.

引用

页码：59 / 64

页数：6

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