ANTIMICROBIAL ACTIVITY OF COPPER(II) COMPLEXES

被引：0
|
作者：
Congradyova, Andrea [1 ]
Jomova, Klaudia [1 ]
Kuckova, Lenka [2 ]
Kozisek, Jozef [2 ]
Moncol, Jan [2 ]
Valko, Marian [2 ]
机构：
[1] Constantine Philosopher Univ, Dept Chem, Fac Nat Sci, Tr A Hlinku 1, Nitra 94974, Slovakia
[2] Slovak Tech Univ, Dept Phys Chem, Fac Chem & Food Technol, Bratislava 81237, Slovakia
来源：
JOURNAL OF MICROBIOLOGY BIOTECHNOLOGY AND FOOD SCIENCES | 2014年 / 3卷
关键词：
5-chlorosalicylic acid; antimicrobial activity; copper complex; 1,10-phenanthroline; neocuproine;
D O I：
暂无
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Two novel copper(II) 5-chlorosalicylate complexes with either 1,10-phenantroline or its methyl derivative 2,9-dimethyl-1,10-phenanthroline (neocuproine) have been prepared and studied. A potential antimicrobial or antifungal activity of both complexes has been tested on prokaryotic Escherichia coli and eukaryotic Saccharomyces cerevisiae model organisms. Crystal structure of [Cu(phen)(5-Clsal)(5-ClsalH(2))](2) a dimeric structure, whereas the second complex of formula [Cu(H2O)(5-Clsal)(Neo)] has been shown to be monomeric. Our results confirmed the toxic effect of prepared copper complexes as well as bioactive ligands on the yeast and bacteria growth. The effect of copper complexes was stronger compared to the solutions of free ligands. Our preliminary results showed that the complex [Cu(H2O)(5-Clsal)(Neo)] exhibited higher antimicrobial activity compared to the complex [Cu(phen)(5-Clsal)(5-ClsalH(2))](2).
引用
收藏
页码：67 / 70
页数：4
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