EFFECTS OF CIMETIDINE AND TROXIPIDE ON GASTRIC-MUCOSAL PROSTAGLANDIN SYNTHESIS IN PATIENTS WITH CHRONIC GASTRIC-ULCER

被引：0
|
作者：
MINE, T [1 ]
KATAOKA, A [1 ]
FUJISAKI, J [1 ]
SATO, E [1 ]
YASUDA, H [1 ]
AKIMOTO, K [1 ]
OGATA, E [1 ]
SEKIGUCHI, H [1 ]
HAMADA, K [1 ]
机构：
[1] KYORIN PHARMACEUT CO LTD,CENT RES LABS,TOKYO,JAPAN
来源：
CURRENT THERAPEUTIC RESEARCH-CLINICAL AND EXPERIMENTAL | 1991年 / 50卷 / 06期
关键词：
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The effects of cimetidine and troxipide were investigated on prostaglandin synthesis in the gastric mucosa of patients with chronic gastric ulcers. Mucosal biopsy specimens of normal and damaged gastric mucosa were obtained by endoscopy before and after one month of treatment with cimetidine alone or the combination of cimetidine plus troxipide. Prostaglandin synthesis was assessed by measuring the in vitro conversion of [C-14]arachidonic acid into various prostaglandins. In the damaged gastric mucosa located around the ulcers, treatment with cimetidine plus troxipide increased the synthesis of prostaglandins E2 and D2 approximately twofold, while cimetidine alone had no effect. These results suggest that troxipide in combination with cimetidine might prove to be a useful regimen for the treatment of chronic gastric ulcer.
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页码：878 / 887
页数：10
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