Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix

被引：6
|
作者：
Ong, Shawn Y. [1 ]
Taverna, Josephine [2 ]
Jokerst, Clint [3 ]
Enzler, Thomas [4 ]
Hammode, Emad [4 ]
Rogowitz, Elisa [5 ]
Green, Myke R. [6 ]
Babiker, Hani [2 ,7 ]
机构：
[1] Univ Arizona, Coll Med, Tucson, AZ 85724 USA
[2] Univ Arizona, Ctr Canc, 1501 N Campbell Ave, Tucson, AZ 85724 USA
[3] Univ Arizona, Coll Med, Dept Radiol, Tucson, AZ 85724 USA
[4] Univ Arizona, Coll Med, Dept Med, Tucson, AZ 85724 USA
[5] Scripps Hlth, Dept Med, La Jolla, CA 92037 USA
[6] Univ Arizona, Med Ctr, Dept Pharm Serv, Tucson, AZ 85724 USA
[7] HonorHlth Res Inst, Virginia G Piper Canc Ctr Clin Trials, Scottsdale, AZ 85258 USA
来源：
CASE REPORTS IN ONCOLOGICAL MEDICINE | 2015年 / 2015卷
关键词：
D O I：
10.1155/2015/212543
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Disseminated intravascular coagulation (DIC) with excessive fibrinolysis (XFL) is a rare and acute life-threatening variant of DIC in patients with prostate cancer. Patients present with coagulopathy, hypofibrinogenemia, and systemic bleeding. We describe a case of DIC XFL caused by prostate cancer (PC) successfully treated with a single injection of degarelix, a gonadotropin-releasing hormone (GnRH) receptor antagonist. This led to prompt control of the patient's coagulopathy within ten days of treatment. Our case highlights features of this rare and devastating hemorrhagic complication of PC along with a fast-acting and effective therapeutic drug option.
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页数：6
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