Prostate Cancer-Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis Treated with Degarelix

被引：6

作者：

Ong, Shawn Y. ^{[1
]}

Taverna, Josephine ^{[2
]}

Jokerst, Clint ^{[3
]}

Enzler, Thomas ^{[4
]}

Hammode, Emad ^{[4
]}

Rogowitz, Elisa ^{[5
]}

Green, Myke R. ^{[6
]}

Babiker, Hani ^{[2
,7
]}

机构：

[1] Univ Arizona, Coll Med, Tucson, AZ 85724 USA

[2] Univ Arizona, Ctr Canc, 1501 N Campbell Ave, Tucson, AZ 85724 USA

[3] Univ Arizona, Coll Med, Dept Radiol, Tucson, AZ 85724 USA

[4] Univ Arizona, Coll Med, Dept Med, Tucson, AZ 85724 USA

[5] Scripps Hlth, Dept Med, La Jolla, CA 92037 USA

[6] Univ Arizona, Med Ctr, Dept Pharm Serv, Tucson, AZ 85724 USA

[7] HonorHlth Res Inst, Virginia G Piper Canc Ctr Clin Trials, Scottsdale, AZ 85258 USA

来源：

CASE REPORTS IN ONCOLOGICAL MEDICINE | 2015年 / 2015卷

关键词：

D O I：

10.1155/2015/212543

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Disseminated intravascular coagulation (DIC) with excessive fibrinolysis (XFL) is a rare and acute life-threatening variant of DIC in patients with prostate cancer. Patients present with coagulopathy, hypofibrinogenemia, and systemic bleeding. We describe a case of DIC XFL caused by prostate cancer (PC) successfully treated with a single injection of degarelix, a gonadotropin-releasing hormone (GnRH) receptor antagonist. This led to prompt control of the patient's coagulopathy within ten days of treatment. Our case highlights features of this rare and devastating hemorrhagic complication of PC along with a fast-acting and effective therapeutic drug option.

引用

页数：6

共 50 条

[1] Critical Anemia and Disseminated Intravascular Coagulation with Excessive Fibrinolysis in Prostate Cancer
Hirsch, K.
Steinberg, A.
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2020, 201
[2] Prostate cancer with disseminated intravascular coagulation and excessive fibrinolysis (DIC XFL)
Hyman, D. M.
Scher, H. I.
Kampel, L. J.
JOURNAL OF CLINICAL ONCOLOGY, 2010, 28 (15)
[3] Disseminated Intravascular Coagulation with Excessive Fibrinolysis in Prostate Cancer: A Case Series and Review of the Literature
Hyman, David M.
Soff, Gerald A.
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ONCOLOGY, 2011, 81 (02) : 119 - 125
[4] Disseminated Intravascular Coagulation With Excessive Fibrinolysis Following Diagnostic Prostatic Biopsy for Prostate Cancer
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Ilyas, Usman
Tran, Lilian
Amin, Toka
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CUREUS JOURNAL OF MEDICAL SCIENCE, 2022, 14 (10)
[5] Management of cancer-associated disseminated intravascular coagulation
Levi, Marcel
THROMBOSIS RESEARCH, 2016, 140 : S66 - S70
[6] Tranexamic Acid to Treat Life-threatening Hemorrhage in Prostate Cancer Associated Disseminated Intravascular Coagulation with Excessive Fibrinolysis
Prokopchuk-Gauk, Oksana
Brose, Kelsey
CUREUS, 2015, 7 (12):
[7] DISSEMINATED INTRAVASCULAR COAGULATION AND EXCESSIVE FIBRINOLYSIS IN A PATIENT WITH METASTATIC PROSTATE-CANCER - RESPONSE TO EPSILON-AMINOCAPROIC ACID
COOPER, DL
SANDLER, AB
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DUFFY, TP
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[8] Fibrinolysis in disseminated intravascular coagulation
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SEMINARS IN THROMBOSIS AND HEMOSTASIS, 2001, 27 (06): : 633 - 638
[9] DISSEMINATED INTRAVASCULAR COAGULATION AND FIBRINOLYSIS
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JOURNAL DE MEDECINE DE STRASBOURG, 1981, 12 (06): : 437 - 439
[10] DISSEMINATED INTRAVASCULAR COAGULATION AND PROSTATE CANCER
PROST, A
BLAT, E
AUVINET, B
COTTIN, S
OUEST MEDICAL, 1976, 29 (23): : 1717 - 1723

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