ACTIVATION OF BLOOD-COAGULATION AND FIBRINOLYSIS IN GRAVES-DISEASE

被引：29
|
作者：
MARONGIU, F [1 ]
CONTI, M [1 ]
MURTAS, ML [1 ]
MAMELI, G [1 ]
SORANO, GG [1 ]
MARTINO, E [1 ]
机构：
[1] UNIV CAGLIARI,CATTEDRA ENDOCRINOL,I-09100 CAGLIARI,ITALY
来源：
HORMONE AND METABOLIC RESEARCH | 1991年 / 23卷 / 12期
关键词：
GRAVES DISEASE; FIBRINOGEN; FIBRINOPEPTIDE A; BLOOD COAGULATION; FIBRINOLYSIS; B-BETA-15-42;
D O I：
10.1055/s-2007-1003766
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
We studied blood coagulation and fibrinolysis activities in hyperthyroidism before and after methimazole or I-131. Fibrinopeptide A and B-beta 15-42, in vivo indicators of thrombin and plasmin activity, were measured by RIA, while fibrinogen by the Clauss method. We studied 50 patients, affected by toxic diffuse goiter. We evaluated 21 of them before and after treatment. Fibrinogen, fibrinopeptide A, and B-beta 15-42 were higher in patients than in controls (p < 0.0001). There was no difference in fibrinopeptide A nor in B-beta 15-42 before or after treatment. In euthyroidism fibrinogen returned to normal values. Inflammation of the thyroid gland secondary to autoimmunity may activate blood coagulation by release of tissue factor. High fibrinogen before treatment may be explained as an aspecific response. Since it persists in euthyroidism, autoimmunity could account for high fibrinopeptide A and B-beta 15-42 after treatment.
引用
收藏
页码：609 / 611
页数：3
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