TRANSPORT OF STEROID-HORMONES FACILITATED BY SERUM-PROTEINS

被引:15
|
作者
WATANABE, S [1 ]
TANI, T [1 ]
WATANABE, S [1 ]
SENO, M [1 ]
机构
[1] UNIV TOKYO,INST IND SCI,TOKYO 113,JAPAN
关键词
STEROID HORMONE TRANSPORT; SERUM PROTEIN CARRIER; LIQUID MEMBRANE SYSTEM; BINDING COEFFICIENT; PARTITION COEFFICIENT;
D O I
10.1016/0304-4165(91)90132-Z
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
The affinities with steroid hormones (alpha-estradiol, ethynylestradiol, progesterone, androsterone, dehydroisoandrosterone and testosterone) were observed for Cohn's fraction IV-1 and V (albumin). It was estimated from the comparison with the binding coefficient K (protein-bound form/free form of hormone) in a 3.5% (w/v) bovine serum albumin (BSA) solution that 40-80% of bound hormone in bovine serum is the BSA-bound form. It becomes clear in a liquid membrane system consisting of a hexane source phase (I), a water phase and a hexane receiving phase (II) that the transport flux of hormone is governed primarily by the partition coefficients between the water/hexane phases. In the case of a hormone with a lower partition coefficient, the uptake process from the hexane phase (I) to the water phase is a rate-determining step in the transport system and the serum proteins accelerate the transport of hormones, while with an increase in the partition coefficient the rate-determining step changes from the uptake step to the release step from the water phase to the hexane phase (II) and the hormone transport is decelerated owing to the significant decrease of free hormone concentration in the aqueous phase by the associated with serum proteins for the system having the restricted amount of hormone in the hexane source phase.
引用
收藏
页码:275 / 284
页数:10
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