RECTAL ABSORPTION OF MORPHINE FROM CONTROLLED-RELEASE SUPPOSITORIES

被引：8
|
作者：
MOOLENAAR, F
MEYLER, P
FRIJLINK, E
JAUW, TH
VISSER, J
PROOST, H
机构：
[1] PHARM ZEEBURG,1019 AT AMSTERDAM,NETHERLANDS
[2] PIJNWERKGRP AZG,9713 EZ GRONINGEN,NETHERLANDS
来源：
INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1995年 / 114卷 / 01期
关键词：
MORPHINE; RECTAL ABSORPTION; CONTROLLED RELEASE; MS CONTIN;
D O I：
10.1016/0378-5173(94)00219-U
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
The absorption profiles and bioavailability of morphine in human volunteers (n = 13) were described after oral administration of MS Contin tablets and rectal administration of a newly developed controlled release suppository. By manipulating the viscosity of fatty suppository base an entirely identical cumulative morphine input could be obtained compared with oral dosing.
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页码：117 / 120
页数：4
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