METABOLISM OF PREGNENOLONE BY HUMAN-BREAST CANCER - EVIDENCE FOR 17-ALPHA-HYDROXYLASE AND 17,20-LYASE

被引:20
|
作者
ABULHAJJ, YJ [1 ]
IVERSON, R [1 ]
KIANG, DT [1 ]
机构
[1] UNIV MINNESOTA,DEPT MED,MINNEAPOLIS,MN 55455
关键词
D O I
10.1016/0039-128X(79)90094-1
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
引用
收藏
页码:817 / 827
页数:11
相关论文
共 50 条
  • [21] Conversion of pregnenolone to DHEA by human 17α-hydroxylase/17,20-lyase (P450c17) -: Evidence that DHEA is produced from the released intermediate, 17α-hydroxypregnenolone
    Soucy, P
    Luu-The, V
    EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (11): : 3243 - 3247
  • [22] Synthesis of novel 21-trifluoropregnane steroids: Inhibitors of 17 alpha-hydroxylase/17,20-lyase (17 alpha-lyase)
    Njar, VCO
    Klus, GT
    Johnson, HH
    Brodie, AMH
    STEROIDS, 1997, 62 (06) : 468 - 473
  • [23] STEROID 17-ALPHA-HYDROXYLASE AND 17,20-LYASE ACTIVITIES OF P450C17 - CONTRIBUTIONS OF SERINE(106) AND P450 REDUCTASE
    LIN, D
    BLACK, SM
    NAGAHAMA, Y
    MILLER, WL
    ENDOCRINOLOGY, 1993, 132 (06) : 2498 - 2506
  • [24] Steroid 17-hydroxylase and 17,20-lyase deficiencies, genetic and pharmacologic
    Auchus, Richard J.
    JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2017, 165 : 71 - 78
  • [25] New insights on hyperglycemia in 17-hydroxylase/17,20-lyase deficiency
    Xu, Lingling
    Lu, Lin
    Tong, Anli
    Chen, Shi
    Li, Wei
    Zhang, Huabing
    Ping, Fan
    Li, Yuxiu
    FRONTIERS IN ENDOCRINOLOGY, 2022, 13
  • [26] DYSREGULATION OF 17-HYDROXYLASE AND 17,20-LYASE IN FUNCTIONAL OVARIAN HYPERANDROGENISM
    BARNES, RB
    ROSENFIELD, RL
    EHRMANN, DA
    SEMINARS IN REPRODUCTIVE ENDOCRINOLOGY, 1993, 11 (04): : 334 - 340
  • [27] Inhibitors of 17α-hydroxylase/17,20-lyase (CYP17):: Potential agents for the treatment of prostate cancer
    Njar, VCO
    Brodie, AMH
    CURRENT PHARMACEUTICAL DESIGN, 1999, 5 (03) : 163 - 180
  • [28] DELETION OF A PHENYLALANINE IN THE N-TERMINAL REGION OF HUMAN CYTOCHROME-P-45017-ALPHA RESULTS IN PARTIAL COMBINED 17-ALPHA-HYDROXYLASE/17,20-LYASE DEFICIENCY
    YANASE, T
    KAGIMOTO, M
    SUZUKI, S
    HASHIBA, K
    SIMPSON, ER
    WATERMAN, MR
    JOURNAL OF BIOLOGICAL CHEMISTRY, 1989, 264 (30) : 18076 - 18082
  • [29] STRUCTURAL CHARACTERIZATION OF NORMAL AND MUTANT HUMAN STEROID 17-ALPHA-HYDROXYLASE GENES - MOLECULAR-BASIS OF ONE EXAMPLE OF COMBINED 17-ALPHA-HYDROXYLASE/17,20 LYASE DEFICIENCY
    KAGIMOTO, M
    WINTER, JSD
    KAGIMOTO, K
    SIMPSON, ER
    WATERMAN, MR
    MOLECULAR ENDOCRINOLOGY, 1988, 2 (06) : 564 - 570
  • [30] THE CYTOCHROME-P45017-ALPHA (17-ALPHA-HYDROXYLASE C17,20-LYASE) ACTIVITY OF THE JUNCTIONAL ZONE OF THE RAT PLACENTA
    JOHNSON, DC
    SEN, M
    JOURNAL OF ENDOCRINOLOGY, 1990, 125 (02) : 217 - 224